The Effect of Aerobic Training before Alzheimer’s Induction on the Expression of Calcineurin and Ca2+/Calmodulin-dependent Protein Kinase II Gene in the Hippocampus of Rats with Alzheimer’s Disease

Background and Objectives Regular aerobic exercise improves learning, memory, cognitive Synaptic Plasticity in Alzheimer’s disease (AD) patients. The aim of this study was to evaluate the levels calcineurin Ca2+/calmodulin-dependent protein kinase II mRNA after four weeks training exercises before AD induction hippocampus male Wistar rats. Subjects Methods Thirty 8-week-old rats with an average weight 195±20 g were initially randomly divided into two groups or rest for weeks. Then, each group three AD, sham, injection. 48 hours last session, Aβ1-42, DMSO injected hippocampus. Finally, isolation hippocampus, CaN CaMKII measured. Results results showed that there a significant difference between (P<0.05). pre-induction had effect on increasing levels. Conclusion Overall, findings present molecular signaling neuroplasticity